Supreme Microbiom
  • Advanced proven formula with live cultures

  • Suitable for use with antibiotics #

  • 100 Billion live cultures in daily dose
    +Fibres +Vitamin B complex

  • 14 Good bacteria strains
    Including LGG +B.coagulans +S.boulardii

There are 100 trillion good bacteria inside the digestive tract, living in perfect balance. Once ingested, to exert their effect, microorganisms need to survive the harsh environment in the upper GI tract and colonize in the lower intestines and colon. Many environmental factors - like diet, stress, smoking, or lifestyle and seasonal changes - may disturb the balance of gut flora, but most aggressive of all are antibiotics.  Good bacteria strains in our formula are selected for their resilience in the harsh conditions that may occasionally occur in the GI tract. All bacterial strains in our formula are well-studied for scientifically documented function. 

14 strains formula

14 strains formula

SUPREME MICROBIOM is made with 14 scientifically studied strains of live cultures, specially designed to deliver good bacteria, combined with vitamin B complex and fibres. The strains in SUPREME MICROBIOM divide quickly and double their mass at approximately 20-minute intervals .



Lactobacilli are a large genus of friendly bacteria that normally inhabit the gastrointestinal tract. An important part of microbial ecosystem in the colon, they produce substances and metabolites like bacteriocins, hydrogen peroxide and organic acids (such as lactic acid ), which is mainly fermented to butyrate, the key nutrient for the epithelial cells of the gut mucosa.
Lactobacilli are one of the most-widely used good bacteria in food supplements. They have a high tolerance to gastric acid and bile, and a capability to adhere to intestinal surfaces. Supreme Microbiom contains a total of 7 strains of Lactobacilli, which contribute to the formula’s strain diversity. They are well- studied, and some come with the highest level of recommendation by the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) and World Gastroenterology Organization (WGO).



Bifidobacteria are y-shaped bacteria, and the first microbes to colonize the human gastrointestinal tract. Researchers have identified more than 50 species of bifidobacterium, with different functions. Bifidobacteria produce several nutrients and metabolites. The availability, diversity, and number of these good bacteria produce metabolites, like short chain fatty acids and vitamins. Bifidobacterium strains of human origin are capable of synthesizing essential vitamins (like K2) and certain B vitamins (like thiamine, riboflavin, pyridoxine, folic acid, biotin, and nicotinic acid). 
The Bifidobacteria strains in Supreme Microbiom (B. breve, B. longum ssp infantis, B. longum, B. bifidum and B. lactis) are among the most well-studied bifido strains used in food supplements.

Bacillus coagulans

Bacillus coagulans

Bacillus coagulans was first isolated from spoiled milk 1915 by B.W. Hammer, at the Iowa Agricultural Experiment Station in the United States of America. A spore-forming bacterium, it’s able to produce lactic acid and various metabolites. 
With the ability to form spores, the bacterial species bacillus coagulans is resistant to extreme conditions and antibiotics. It survives the acidic gastric juice and bile acids in the duodenum while passing through the GI tract, and safely reaches lower intestines and colon, where it divides quickly to colonize the gut. 

Saccharomyces boulardii

Saccharomyces boulardii

Saccharomyces boulardii is a life yeast named after Henri Boulard, the scientist who first isolated it from lychee and mangosteen fruit in 1920. Clinical studies demonstrate the multiple mechanisms of action of this unique microorganism, with its resistance in digestion. It survives gastric acidity and colonizes the intestinal tract. S. boulardii produces polyamines and bacteriocins, and studies have shown that it’s naturally resistant to antibiotics, since they don’t interfere with its metabolism. 

100 Billion CFU in daily dose


The dose of the friendly bacteria is one of the most important condition for the rapid colonization of the digestive tract. According to ESPGHAN (European Society for Paediatric Gastroenterology, Hepatology and Nutrition), the effect of the good bacteria is defined as dose-dependent, i.e. the effect is more pronounced when the number of viable good bacteria (colony-forming unit - CFU) is higher. 
Strain selection of a friendly bacteria formula is another important factor affecting its quality. 
We designed Supreme Microbiom to provide a daily dose of 100 billion live cultures in compliance with the latest scientific requirements for strain variety and quality.

Vitamin B complex

vitamin B complex

B vitamins are water-soluble vitamins that play an important role in many physiological processes. Many studies highlight their unconditional connection to human life:
•    Vitamin B6 and B2 are responsible for maintenance of normal of red blood cells
•    Folic acid and vitamin B6 are key factors in maintaining healthy immune system
•    Biotin contributes to normal metabolism 
•    B vitamins (like biotin, niacin, riboflavin, thiamine, pyridoxine) are vital for converting food into cellular energy
B vitamins are easily obtained through a variety of food, but gut microbiota is probably the most reliable source, as it can synthesize different B vitamins (including biotin, cobalamin, folates, nicotinic acid, panthotenic acid, pyridoxine, riboflavin, and thiamine). However, when there are occasional disruptions of the balanced state of gut microflora, the synthesis of vitamins B is also disrupted; this is when it’s important to supplement additional B vitamins to the diet. 

Soluble fibre blend

Soluble Fibre Blend

Soluble fibres are non-degradable substances (oligosaccharides) that serve as food for life microorganisms that normally live in the intestines, as well as for the strains taken with food supplements with friendly bacteria.
Fibres are selectively good bacteria strains that flourish when sources of food and energy are abundant. Supreme Microbiom contains a soluble fibre blend of three different types of oligosaccharides - FOS, XOS and MOS - specially selected to meet the needs of each strain included in our formula and assist them to start dividing rapidly.

The capsule


The capsule is gastro-resistant, and does not dissolve in the stomach and duodenum, protecting the good bacteria from acidic gastric juice and bile acids. It’s designed to dissolve in the initial part of the small intestine, delivering the bacteria strains in the friendly environment where they begin to multiply.

Supreme Microbiom is manufactured in Bulgaria,
the homeland of probiotics, where the first Lactobacillus was discovered.


Directions: Take 1 capsule daily; during antibiotic intake, increase dosage to 2 per day. Do not take SUPREME MICROBIOM with hot or alcoholic beverages.

CAUTION: Consult a physician if you are pregnant or nursing, taking medication, or if you have a medical condition. Keep out of reach of young children. Do not exceed recommended daily dose. Food supplements should not be used as a substitute for a varied diet and healthy lifestyle.
# Suitable for use with antibiotics, but please seek guidance from a medical professional.

STORAGE: Store below 25°C in a dry place.

Nutrition Information

Serving Size 2 Capsules

Servings Per Container 14

Per 2 Capsules %RI*
Vitamin В1 (Thiamine) 14 mg 1273%
Vitamin В2 (Riboflavin) 4 mg 286%
Niacin 10 mg NE 63%
Vitamin B6 10 mg 714%
Folic Acid 400 μg 200%
Biotin 500 μg 1000%
Mannan oligosaccharides

26 mg
2 mg
2 mg

Lacto Cultures Of which:
Lactobacillus rhamnosus GG
Lactobacillus acidophilus
Lactobacillus plantarum
Lactobacillus paracasei
Lactobacillus casei
Lactobacillus reuteri
Lactobacillus gasseri
235 mg (56 Billion CFU)
40 mg (12 Billion CFU)
23.4 mg (11 Billion CFU)
29.3 mg (10 Billion CFU)
29.3 mg (10 Billion CFU)
20.5 mg (7 Billion CFU)
35.1 mg (3 Billion CFU)
8.8 mg (3 Billion CFU)
Bifido Cultures Of which:
Bifidobacterium breve
Bifidobacterium bifidum
Bifidobacterium longum ssp infantis
Bifidobacterium longum ssp longum
Bifidobacterium lactis
165 mg (38 Billion CFU)
49.5 mg(15 Billion CFU)
9.9 mg(11 Billion CFU)
33 mg(4 Billion CFU)
16.5 mg(4 Billion CFU)
9.9 mg (4 Billion CFU)
Saccharomyces boulardii 250 mg (5 Billion CFU) **
Bacillus coagulans 10 mg (1 Billion CFU) **
* Reference Intake
** No established Reference Intake
CFU = Colony Forming Units

INGREDIENTS: Lactobacillus cultures, Saccharomyces boulardii, Bifidobacterium cultures, Vegetable capsule shell (Hypromellose, Color [Titanium dioxide]), Bulking agent (Maltodextrin), Fructooligosaccharides, Thiamine Mononitrate, Bacillus coagulans, Nicotinamide, Pyridoxine Hydrochloride, Bulking agent (Magnesium salts of fatty acids), Riboflavin, Xylooligosaccharides, Mannan oligosaccharides, D-biotin, Pteroylmonoglutamic acid